What is "genetic manipulation" mean?  

Genetic modification are terms for the process of manipulating genes, usually outside the organism's natural reproductive process.
It involves the isolation, manipulation and reintroduction of DNA into cells or model organisms, usually to express a protein. The aim is to introduce new characteristics or attributes physiologically or physically, such as making a crop resistant to a herbicide, introducing a novel trait, or producing a new protein or enzyme, along with altering the organism to produce more of certain traits. Examples can include the production of human Insulin through the use of modified bacteria, the production of erythropoietin in Chinese Hamster Ovary cells, and the production of new types of experimental mice such as the OncoMouse (cancer mouse) for research, through genetic redesign.