headache - The brain itself is not sensitive to pain, because it lacks pain-sensitive nerve fibers. Several areas of the head can hurt, including a network of nerves which extends over the scalp and certain nerves in the face, mouth, and throat. The meninges and the blood vessels do have pain perception. Headache often results from traction to or irritation of the meninges and blood vessels. The muscles of the head may similarly be sensitive to pain.