Headache - Caffeine, a vasoconstrictor, is sometimes prescribed or recommended for recovery of headache, as a remedy or supplement to pain killers in the case of extreme migraine. This has led to the development of Tylenol Ultra, a paracetamol/caffeine analgesic. One popular herbal preventive treatment for migraines is Feverfew. Magnesium, Vitamin B2, and Coenzyme Q10 are 'natural' supplements that have shown some efficacy for migraine prevention..