She's my best friend, but....

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Yesterday, I saw a rerun of the Rachel Ray show, and she was talking to a mom/daughter combo that claimed to be best friends. But they were always bickering. And, I wondered if you could really be best friends with someone that disagreed with you all the time, or took every chance to critque you? Would you be friends like that with someone who went out of their way to be spiteful or a little mean, even if that person were your mom? What would you change about your best friend if you could? Would you make her less judgemental? Would you make her smarter, if you could? More stylish? Please share.