How do deal with guilt ?

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Many of us do some mistakes in life which affect the lives of others around us. I am not talking about drastic things like taking someones life, but about things like lying, betraying someones trust in you or causing some one to make a decision based on you inputs. Saying sorry or apologising may be the easiest thing to do, but what about your own concience ? How does one make that feeling of guilt go away before it does to much damage to yourself.