What type of mouse do you have?

It is very important to find one particular hardware or any object that is suitable to your body so that you during work , you should get relaxed and safety should be there. As you saying that your hand size is big, i suggest to you go through Dell Optical mouse. Its motion speed as well as capability of catching pixel point is very good. Also windows automatically installs required drivers. I mean it is compatible with windows as well as Linux.

I use logitech MX1000 laser mouse never had problem with lag or batteries going flat on me i put back on charger every night for last 2 years,i had mx510 corded and it was fantastic as well but hated the cord getting in the way to much....

I have a Logitech Cordless Mini Optical Mouse. It works great for me. It's just about the regular size of a mouse, not too big and not too small. I recommend that you try one. Hope this helps.

I use an A4-Tech Skid free mouse. i find it really easy to use. even though it's optical, it's doesn't skip places. i suggest that you get a usb optical mouse. choose a good and know brand. based on experience, reliability and lifespan of cheap brands are usually low. small mouse are hard to use but if your using a laptop, thats more advisable. Skip the wireless type, unless you don't have any bad experiences with it.

I'm using microsoft laser wireless mouse. So far I quite like the confirm of it. is slidely bigger then normal mini mouse. I guess you should try out few of the mouses before you buy, since you know what ur looking for now.

From last three years I've been using Microsoft's wire Lesser mouse, it is working perfectly.

For my desktop I use the corded mouse that came with my Dell and it is fine; the shape is suited for either right or left handed since it has no curvature. For my laptop I use the built in one but do not use the laptop enough that I have gotten used to it and therefore it is not comfortable for me. If I used the laptop more I would get a regular mouse but would probably avoid a mini and would go with the cheapest I could find.

Maybe you can make one