What might be the difference?

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We all know that E=mc^2.So it means a 50 kg mass has a corresponding energy.Now then tel me the difference between a 50kg weighing man and a 50 kg stone?Both have the same quantity of energy,then why can,t stones have same characteristics as the humans.Why could't they too develope the same genetic physical and biological properties,After all its all energy and mass that are the basic entities.