How do you deal with having friends you can't count on ???

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I am in a situation where I have a friend I just can't count on. We have been friends since we were in first grade together. I was there for her through anything and everything and she was for me. Recently her dad died and I was there for her in every way. Holding her hand and crying for her. I didn't leave her side through the day of her dad's funeral. Then a couple weeks ago when I thought me and my b/f were splitting up I called her, but she wouldn't answer her phone. I left her this hysterical messege as I was crying uncontrolably. She never called me back. I even left her a messege on another site for her to call me and to let her know me and my b/f were still together, but I haven't heard a word from her. What would any of you do in this situation? Would you just not talk to your friend anymore? I have always tried to be the best friend I can to any of my friends and to always be there for them when they need me. Right now I'm re-thinking my friendship with her. Her and her mom are friends with my b/f and they won't even talk to him anymore. I find it odd that friends would be this way.