A Male Contraceptive Targeting Germ Cell Adhesion
@kapilgoela123 (134)
India
November 4, 2006 3:55am CST
Here, they report a novel approach in which Adjudin is specifically targeted to
the testis by conjugating Adjudin to a recombinant follicle-stimulating
hormone (FSH) mutant, which serves as its 'carrier'.
Using this approach, infertility was induced in adult rats when 0.5 g Adjudin per
kg b.w. was administered intraperitoneally, which was similar to
results when 50 mg per kg b.w. was given orally. This represents a
substantial increase in Adjudin's selectivity and efficacy as a male
contraceptive.Throughout spermatogenesis, developing germ cells remain attached to
Sertoli cells via testis-specific anchoring junctions. If adhesion
between these cell types is compromised, germ cells detach from the
seminiferous epithelium and infertility often results.
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