What should be the biggest mistake you have done in your life?

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Well, for me.. the biggest damn thing i have done in my life, when i change my workmate's password in her facebook... and i was been able to paid-off for that because she hates me now... and i am her number 1 suspect to that mistake i have done.. because i forgot what was the password i changed... i hate myself... how about you? what should be your biggest mistake?