Ok drugs no ok drugs

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Ok I had no idea what to title this. But my question here is what do you think is the worst drug out there and what do you think is the most harmless. I mean everything from cigarettes and caffeine to the hardest drugs out there, illegal and legal. Anything that changes your state of mind in some sort of way is considered a drug. I mean think people get addicted to shopping. So what is the most harmless drug and most dangerous?