What do you do?

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Okay so here's the conflict, my best friend's brother is going through something that's starting to really get to him. Just reciently his girlfriend dumped him then went right to his friend. It hasn't even been a week and she already found someone else, now she wont leave him alone. I keep thinking that she's just doing all of this to hurt him and piss him off, but the thing is now he's lost a friend because of her. Also, this girl is turning all of his friends against him, even the whole school. Now he doesn't know what to do, he can't go back to that school with all of this happening. So he decided to go and live with his dad, which is now starting to hurt my friend. Because this girl has done all this stuff to him and has hurt him so is starting to piss me off to the limit. They were together for one year and five months, being together that long you'd think you really know someone. I guess she's nothing more than a good liar. This is something that is really getting to me, they were together for that long then one day she just comes out and tells him that she's bored with him, so she leaves him. What the hell is that all about? I mean really. This is so messed up and because I know him so well, he's a really sweet guy. I think of him as a little brother and now because of her I want to do nothing more than to go over to her house and curse her out to no extent. What can I do to help him through this? If this is to continue how can I make sure he will be just fine?