Do you ignore phone calls from unknown numbers?

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Whenever I get a call from a number I do not know I never pick up. Sometimes I am nervous or scared to pick up the phone, but usually it's because it could be telemarketing or spam calls, which I do not want to deal with. So, what I do is just ignore the calls, and then go to White Pages online and do a reverse phone look up to see who called me. The thing is, unless it's a home phone number, it usually doesn't say who it is that called. But I can find out if the spam risk is high or low, which is rather helpful. Maybe it's not a good thing to ignore the calls, but I figure if it's important, the person calling will leave a message, and I can always call that person back if I think I should. There are people though that simply do not leave messages. In that case I am out of luck... I remember I used to get calls from someone saying they are from the IRS investigating department. I wouldn't pick up the phone. They'd leave a long message telling me there is a warrant for my arrest and asking me to call them back. Of course, I never did, so they'd call back from the same number or from a different number altogether. Usually it'd be the same person, but sometimes not. I knew that this was spam and I never fell for this, but I've heard that there were people that did and gave up their personal info, including bank account info. Do you ignore calls from numbers you do not know? Have you ever had the same number call you back time and time again?