Using of Cortico Steroids in Children causes Vitamin D loss ... ALERT !!!

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Decreased serum vitamin D levels in children with asthma are associated with increased cortico steroid use source: familydoctoronline.info/forum There is little knowledge about clinical variables associated with vitamin D (VitD) insufficiency in asthmatic children. When a research-group sought to investigate disease variables associated with Vit-D insufficiency in patients with childhood asthma and interaction of Vit-D with corticosteroid-mediated anti-inflammatory responses. They analyzed 25-hydroxyvitamin D serum levels in 100 asthmatic children to investigate relationships between 25-hydroxyvitamin D levels and patients' characteristics. And determined Vit-D's effects on dexamethasone (DEX) induction of mitogen-activated protein kinase phosphatase 1 and IL-10 in PBMCs. Corticosteroid use and worsening airflow limitation are associated with lower Vit-D serum levels in asthmatic patients. VitD enhances glucocorticoid action in PBMCs from asthmatic patients and enhances the immunosuppressive function of DEX in vitro.