1997 buick lesabre 3800 series II engine with P0306 code  

I have a 1997 buick Lesabre limited with v6 3800 series II engine (about 140,000 miles). was running like a top. While entering traffic on a highway (moderate acceleration), car started to 'buck'/miss. car continues to not run well. check engine light came on (flashed first then steady). diagnostic code P0306 (cylinder 6 misfire detected is translation from code book I have). What the hell does that mean?? Can someone point me in the right direction......am I corerect in assuming this is an ignition type problem like coil, etc?? PLEASE HELP!!!