Do you find it weird/ difficult when you change your computer mouse?  

Yes! I recently got a laptop and a small, cheap mouse for it(can't stand the touchpad...) When I went on the family computer, the size of the old mouse seemed huge!

lol you will get use to it in time and i am sure about it because i experienced that before too.

i have to tell you something what really strange me is when the time i am going to change my keyboard lol i am not able to hit the right key to type but when i am use to its too easy. it is like the mouse lol

I've been using only optical USB rodents for my last few replacements...they're easy to replace,being plug and play devices under newer variants of windows..my only problem with mice is, being a lefty,not realising it when I bought it,had a couple of buttons where I would normally grip my mouse...that didn't work out...fortunately,that one seemed to be part lemming,as it kept falling off my desk to the point it broke..it's replacement,still working just fine,doesn't have any extra buttons...but WHY does it need to have a Blue LED that stays on all the time to let me know it's plugged in?! it's like having a blue flashlight..

I changed my mouse about a year ago. I bought a new wireless mouse and keyboard. The mouse just flies along. It is quite large and it took me a long time to get used to it. But now I find it very comfortable to use and I wouldn't ever go back to using an ordinary mouse, that is of course, unless I had to.